Publications / Scientific Presentations

Publications

Distinguishing analgesic drugs from non-analgesic drugs based on brain activation in macaques with oxaliplatin-inducued neuropathic pain.

Shidahara Y., Natsume T., Awaga Y., Ogawa S., Yamoto K., Okamoto S., Hama A., Hayashi I., Takamatsu H., Magata Y.

Neuropharmacology. 2019 Feb 25. https://doi.org/10.1016/j.neuropharm.2019.02.031.

Pain-related behavior and brain activation in cynomolgus macaques with naturally occurring endometriosis.

Yano M., Matsuda A., Natsume T., Ogawa S., Awaga Y., Hayashi I., Hama A., Takamatsu H.

Human Reproduction. 2018 Dec 31. https://doi.org/10.1093/humrep/dey383.

Pain-Related Behavior and Brain Activation in a Cynomolgus Macaque Model of Postoperative Pain.

Hama A., Natsume T., Ogawa S., Awaga Y., Hayashi I., Matsuda A., Takamatsu H.

CNS & Neurological Disordders - Drug Targets. 2018 May 15. doi: 10.2174/1871527317666180515121350.

Gaps in Understanding Mechanism and Lack of Treatments: Potential Use of a Nonhuman Primate Model of Oxaliplatin-Induced Neuropathic Pain

Hama A., Natsume T., Ogawa S., Higo N., Hayashi I., Takamatsu H.

Pain Research and Management. Volume 2018 Article ID 1630709 

Brain activity changes in a macaque model of oxaliplatin-induced neuropathic cold hypersensitivity

Nagasaka, K., Yamanaka, K., Ogawa, S., Takamatsu, H., Higo, N.

Scientific reports. 2017; 7:4305.

Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson’s disease patients

Saito, Y., Akazawa-Ogawa, Y., Matsumura A., Saigoh, K., Itoh, S., Sutou, K., Kobayashi, M., Mita, Y., Shichiri, M., Hisahara, S., Hara, Y., Fujimura, H., Takamatsu, H., Hagihara, Y., Yoshida, Y., Hamakubo, T., Kusunoki, S., Shimohama, S. & Noguchi, N.

Scientific Reports. 2016; 6: 30793

Antinociceptive effect of clinical analgesics in a nonhuman primate model of knee osteoarthritis

Ogawa, S., Awaga, Y., Takashima, M., Hama, A., Matsuda, A., Takamatsu, H.

European Journal of Pharmacology. 2016 Sep; 786: 179-185

Knee osteoarthritis pain following medial meniscectomy in the nonhuman primate

Ogawa, S., Awaga, Y., Takashima, M. Hama, A., Matsuda, A., Takamatsu, H.

Osteoarthritis and Cartilage. 2016 Jul; 24(7): 1190 - 9

Pharmacological comparison of a nonhuman primate and a rat model of oxaliplatin-induced neuropathic cold hypersensitivity

Shidahara, Y., Ogawa, S., Nakamura, M., Nemoto, S., Awaga, Y., Takashima, M., Hama, A., Matsuda, A., Takamatsu, H.

Pharmacology Research & Perspectives. 2016; 4(1): e00216

Chemotherapy-Induced Peripheral Neuropathic Pain and Rodent Models.

Hama, A., Takamatsu, H.

CNS & neurological disorders drug targets. 2016; 15(1): 7-19.

Beyond Rodent Models of Pain: Non-Human Primate Models for Evaluating Novel Analgesic Therapeutics and Elaborating Pain Mechanisms.

Hama, A., Toide, K., Takamatsu, H.

CNS & Neurological Disorders - Drug Targets (Formerly Current Drug Targets - CNS & Neurological Disorders). 2013 Dec; 12(8): 1257 - 70.

Scientific presentations

Effect of Prednisolone and Vedolizumab on a Newly Developed Chronic Dextran Sulfate Sodium-Induced Colitis Model in the Nonhuman Primate.

Takahashi et al.

Digestive Disease Week; 2019 May 18-21; San Diego, CA

Development of a macaque model of dry, nonexudative from age-related macualr degeneration with geographic atrophy.

Takahashi et al.

The Association for Research in Vision and Ophthalmology; 2019 April 28 - May 2; Vancouver, British Columbia, Canada

Tracking of disease progression over time with optic nerve diffusion tensor imaging and retinal nerve fiber layer thickness in macaques with experimental galucoma.

Takahashi et al.

The Association for Research in Vision and Ophthalmology; 2019 April 28 - May 2; Vancouver, British Columbia, Canada

Development of a Chronic Dextran Sulfate Sodium-Induced Colitis Model in the Nonhuman Primate.

Takahashi et al.

United European Gastroenterology (UEG) Week Vienna 2018; 2018 October 20-24, Vienna, Austria

Pharmacological Modulation of Brain Activation and Pain-Related Behavior in Cynomolgus Macaque Models of Pain.

Hama et al.

17th World Congress on Pain; 2018 September 12-16; Boston, MA

Brain activation and pain-related behavior in a nonhuman primate model of experimental postoperative pain.

Yamoto et al.

WCP2018 KYOTO 18th World Congress of Basic and Clinical Pharmacology; 2018 July 1-6; Kyoto, Japan

Pharmacological Modulation of Pain-Related Brain Activation in Nonhuman Primates Models of Pain.

Yano et al.

Laboratory Animal Sciences 2018; 2018 Feb 7-8; LabRoots.

Neuroimaging of Pain-Related Brain Activation in Nonhuman Primates Pain Models.

Natsume et al.

American Association of Pharmaceutical Scientists 2017; 2017 Nov 12-15; San Diego, CA.

Pain-related behavior, pharmacological characterization and brain activation of nonhuman primates with naturally-occurring endometriosis.

Matsuda et al.

11th Annual Pain & Migraine Therapeutics SUMMIT; 2017 Sep 27-28; San Diego, CA.

Evaluation of clinical analgesics in a nonhuman primate model of knee osteoarthritis.

Ogawa et al.

11th Annual Pain & Migraine Therapeutics SUMMIT; 2017 Sep 27-28; San Diego, CA.

Brain activation in a nonhuman primate model of oxaliplatin-induced peripheral neuropathy: suppression with duloxetine.

Natsume et al.

11th Annual Pain & Migraine Therapeutics SUMMIT; 2017 Sep 27-28; San Diego, CA.

Brain activation and suppression with morphine in a nonhuman primate model of postoperative pain.

Hama et al.

11th Annual Pain & Migraine Therapeutics SUMMIT; 2017 Sep 27-28; San Diego, CA.

Characterization of Acute Stoke Induced by Photochemically-induced Thrombosis (PIT) in Nonhuman Primate (NHP).

Tanaka et al.

International Stroke Conference 2017; 2017 Feb 22-24; Houston, TX.

 

Functional Recovery Following a Combination of Thrombin Inhibitor Argatroban and Tissue Plasminogen Activator (tPA) in Thromboembolic Stroke in Nonhuman Primates.

Hayashi et al.

Poster presented at: International Stroke Conference 2017; 2017 Feb 22-24; Houston, TX.

Comparison of tissue plasminogen activator (tPA) alone and in combination with thrombin inhibitor argatroban in a nonhuman primate model of thromboembolic stroke.

Suzuki et al.

Poster presented at: Society for Neuroscience 2016 Annual Meeting; 2016 Nov 12-16; San Diego, CA.

 

A nonhuman primate model of oxaliplatin-induced neuropathic pain.

Shidahara et al.

16th World Congress on Pain; 2016 Sep 26-30; Yokohama, Japan.

 

Pharmacological profile of a novel nonhuman primate model of knee osteoarthritis.

Ogawa et al.

16th World Congress on Pain; 2016 Sep 26-30; Yokohama, Japan.

 

Brain activity in a nonhuman primate model of oxaliplatin–induced neuropathic cold hypersensitivity.

Nagasaka et al.

16th World Congress on Pain; 2016 Sep 26-30; Yokohama, Japan.

 

Analgesic effects of the novel α2δ ligand mirogabalin (DS-5565) in spinal cord injury model rats.

Domon et al.

16th World Congress on Pain; 2016 Sep 26-30; Yokohama, Japan.

 

Differential effects of clinical analgesics in a nonhuman primate and rat model of oxaliplatin-induced peripheral neuropathy.

Shidahara et al.       

The 89th Annual Meeting of The Japanese Pharmacological Society; 2016 Mar 9-11; Yokohama, Japan.

 

Pharmacological profile of knee osteoarthritis in a novel nonhuman primate model.

Ogawa et al.

The 89th Annual Meeting of The Japanese Pharmacological Society; 2016 Mar 9-11; Yokohama, Japan.

 

Pain-related behaviors in nonhuman primate models of knee osteoarthritis.

Nemoto et al

Society for Neuroscience 2015 Annual Meeting; 2015 Oct 17-21; Chicago, IL.

 

A comparison between nonhuman primate and rat models of acute chemotherapy-induced peripheral neuropathy.

Shidahara et al.      

Society for Neuroscience 2015 Annual Meeting; 2015 Oct 17-21; Chicago, IL.

 

A nonhuman primate model of knee osteoarthritis (OA) I: Medial meniscectomy (MMx)-induced OA.

Ogawa et al.

The 88th Annual Meeting of The Japanese Pharmacological Society; 2015 Mar 18-20; Nagoya, Japan.

 

A nonhuman primate model of knee osteoarthritis (OA) II: Monoiodoacetate-induced OA.

Nemoto et al.

The 88th Annual Meeting of The Japanese Pharmacological Society; 2015 Mar 18-20; Nagoya, Japan.

 

Testimonials

Noriyuki Higo, PhD
Human Informatics Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8568, Japan

“HPR’s R&D team has amazing capabilities in conducting pharmacological studies, from behavioral characterization to MRI imaging. They have tremendously supported our research!”

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