HPR is an AAALAC-accredited contract research organization providing nonhuman primate (NHP) disease models for preclinical efficacy testing of new therapeutics.
Why NHP?
The macaque is ideal for providing crucial preclinical efficacy data for new therapeutics headed for clinical testing.
Accelerated success
HPR will aid your preclinical drug development process.
Phylogenetic similarity
Nonhuman primates (NHPs) are phylogenetically closer to humans than rodents. The genetic similarity between humans and Old World non-human primates in about 93% (96% with Chimpanzees, and 93% with macaques), while that between humans and rodents is only 85% (Science, 316:222-234 (2007)). In other words: efficacy of a novel therapeutic may be robust in a rodent model but under-whelming in a NHP model despite targeting of the "same" molecular target.
Genetic similarity: rodents, NHPs vs. patients
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mouse
85%
human
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93%
macaque
human
Source: National Human Genome Research Institute and Science 13 Apr 2007:Vol. 316, Issue 5822, pp. 222-234
Anatomic similarity
NHPs are anatomically and neurologically similar to humans than rodents (Nature Reviews Neuroscience,15:655–669 (2014)). Clinical methods can be used for drug administration and clinical protocols for diagnostics, including MRI-based brain activation.
Brains: rodents, NHPs vs. patients
Long history in scientific research
Among NHP, macaques, rhesus and cynomolgus macaques have been most widely used in scientific research due to their responsiveness to training and learning complex tasks and fine motor coordination.
Souce: Liman and Innan, 2003, PNAS, 100:3328-3332.
Source: Rogers and Gibbs, 2014, Nature Reviews Genetics, 15:347–359.
HPR's Laboratory Animal Expertise
HPR performs NHP-focused studies, leveraging extensive experience in translational research and laboratory animal care.
The well-being of laboratory animals is very important to HPR. Hamamatsu Pharma Research has been an AAALAC International-accredited facility since 2015. Staff and veterinarians are fully proficient in NHP care and handling.
