HPR is an AAALAC-accredited contract research organization that provides nonhuman primate (NHP) disease models for preclinical efficacy testing of potential therapeutics.

Why NHP?

NHP, especially the macaques, is ideal for providing higher predictability of clinical efficacy of potential therapeutics than small animals such as rodents.

Accelerated success

HPR will guide you through the process of efficient preclinical drug development.

Phylogenetical similarity

Nonhuman primates (NHPs) are phylogenetically closer to humans than rodents. The genetic similarity between humans and non-human primates is reported to be >90% (96% with Chimpanzees, and 93% with macaques), while that between humans and rodents is only 85% (Science. 316:222-234 (2007)). This can be translated into physiological and pathophysiological similarities of human and NHP, which can provide higher predictability of the test therapeutics efficacy in clinical settings.

Genetic Similarity
vs
mouse
85%
human
vs
93%
macaque
human
Source: National Human Genome Research Institute and Science  13 Apr 2007:Vol. 316, Issue 5822, pp. 222-234

Anatomical similarity

NHPs are also anatomically and neurologically similar to humans than rodents (Nature Reviews Neuroscience. 15:655–669 (2014)). Thanks to this similarity, the same methods can be used for drug administration and diagnostics, including a neurological functional test that employs emotional reads-out (e.g. pain scaling).

Anatomic Similarity

Long history in scientific research

Among NHP species, the macaques, especially rhesus and cynomolgus macaques, have been most widely used in scientific research due to their relatively wide availability and anatomical and physiological closeness to human.  

Emily R. Liman, and Hideki Innan PNAS 2003;100:3328-3332

Source: Rogers and Gibbs (Nature Reviews Genetics. 15:347–359 (2014)) 

Our Animal Expertise

HPR creates highly-trained nonhuman primate models, leveraging our extensive experience in translational research and animal care.

Well-being of animals is very important to us. Hamamatsu Pharma Research is an AAALAC International-accredited facility and our highly skilled staff delivers excellent care to all animals. (Fully accredited by AAALAC on June 19, 2015)

We do not outsource animal care.

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Hamamatsu Pharma Research U.S.A., Inc

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Tel:  +1 (858) 535 - 4819

Fax: +1 (858) 535 - 4890

E-mail: info_us@hpharma.jp