HPR is an AAALAC-accredited contract research organization that provides nonhuman primate (NHP) disease models for preclinical efficacy testing of potential therapeutics.
NHP, especially the macaques, is ideal for providing higher predictability of clinical efficacy of potential therapeutics than small animals such as rodents.
HPR will guide you through the process of efficient preclinical drug development.
Nonhuman primates (NHPs) are phylogenetically closer to humans than rodents. The genetic similarity between humans and non-human primates is reported to be >90% (96% with Chimpanzees, and 93% with macaques), while that between humans and rodents is only 85% (Science. 316:222-234 (2007)). This can be translated into physiological and pathophysiological similarities of human and NHP, which can provide higher predictability of the test therapeutics efficacy in clinical settings.
Source: National Human Genome Research Institute and Science 13 Apr 2007:Vol. 316, Issue 5822, pp. 222-234
NHPs are also anatomically and neurologically similar to humans than rodents (Nature Reviews Neuroscience. 15:655–669 (2014)). Thanks to this similarity, the same methods can be used for drug administration and diagnostics, including a neurological functional test that employs emotional reads-out (e.g. pain scaling).
Long history in scientific research
Among NHP species, the macaques, especially rhesus and cynomolgus macaques, have been most widely used in scientific research due to their relatively wide availability and anatomical and physiological closeness to human.
Emily R. Liman, and Hideki Innan PNAS 2003;100:3328-3332
Source: Rogers and Gibbs (Nature Reviews Genetics. 15:347–359 (2014))
Our Animal Expertise
HPR creates highly-trained nonhuman primate models, leveraging our extensive experience in translational research and animal care.
Well-being of animals is very important to us. Hamamatsu Pharma Research is an AAALAC International-accredited facility and our highly skilled staff delivers excellent care to all animals. (Fully accredited by AAALAC on June 19, 2015)
We do not outsource animal care.