Most common reason to seek medical attention: pain.
Little success in translating laboratory findings to treatments for patients.
Need for a nonsubjective method to measure "pain", a subjective experience.
Comparison of analgesic drugs
for osteoarthritis across species
TBD: To Be Determined
Functional magnetic resonance imaging (fMRI)
(Paramagnetic - decreasing magnetic resonance signals)
Decreasing blood flow
Increasing blood flow
Once nerve cells are activated, local blood flow increases with oxygenated hemoglobin to supply oxygen, and the ratio of deoxygenated hemoglobin, which distorts local magnetic fields, decreases. This results in increased magnetic resonance signals.
Brain activation = Increased MRI signal
PAG periaqueductal grey
S2 secondary somatosensory area
High brain activity
Nature Reviews Neurology 5(4):199-209, 2009
Stimulation for fMRI
Minimum 10 sets (15 minutes)
OFF/ON 1 set:
30 sec, 10 frames
OFF : resting state
ON : pain state
After scanning, a statistical map is produced, showing areas of activation following stimulation. The brain activation is statistically calculated by analyzing "OFF" and "ON" data sets.
x : a raw score
µ : mean
σ : standard deviation
if z > 1.96, p < 0.05
fMRI can be applied to various NHP pain models
In vivo brain activation can be observed across NHP pain models
Chemotherapy-induced neuropathic pain
Sciatic nerve ligation
*Information described in this page is referred from the following publications.
Hama et al. Pain Research and Management. 2018
Ogawa et al. European Journal of Pharmacology. 2016
Ogawa et al. Osteoarthritis and Cartilage. 2016
Hama et al. CNS & Neurological Disorders - Drug Targets. 2016
Hama et al. CNS & Neurological Disorders - Drug Targets. 2013
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