Pharmacological Studies

HPR specializes in efficacy testing of therapeutics in cynomolgus macaque disease models.

We also provide pharmacological consultation for your research and development programs. 

HPR's Primate Center and Central Research Facility are located in Hamamatsu, Japan.

Central Nervous System
  • Stroke
    • Photochemically-induced thrombosis (PIT)

    • Thromboembolic

    • Transient and permanent occlusion

  • Neurological disease

    • Parkinson's disease

  • Capsaicin-induced acute pain

  • Oxaliplatin-induced polyneuropathic pain

  • Postoperative pain

  • Visceral pain

  • Peripheral monneuropathic pain

  • Osteoarthritis (OA)

  • Age-related macular degeneration

    • dry AMD and wet AMD

  • Glaucoma

  • Inflammatory bowel disease (IBD)

  • Visceral pain/Irritable bowel syndrome (IBS)

Other Therapeutic Areas
  • Cardiovascular disorders

    • Thrombosis

  • Reproductive diseases

    • Naturally-occuring endometriosis 

  • Skin disorders

    • Pruritus

HPR Therapeutic Studies
HPR pain model
HPR Visceral pain model
HPR OA model
HPR Stroke model
HPR Endometriosis
HPR IBD (UC) model
HPR Dry AMD model
HPR Wet AMD model
HPR Glaucoma model
HPR Pruritus model
HPR Thrombosis model
HPR Parkinson's Disease model
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Our services

When it comes to designing a preclinical pharmacological study, a well thought out process-flow, appropriate selection of an animal model and well defined experimental endpoints are critical.

With HPR’s expertise in preclinical pharmacology, your study will be fully supported every step of the way.

Study Consultation
  • Study protocol design utilizing a NHP disease model

  • Study planning and execution

Disease Model Customization
  • Customization of existing models

  • New model development

Pharmacological Studies
  • Primary therapeutic areas:
    Pain, Stroke, Endometriosis, OA, AMD, Glaucoma, IBD, Thrombosis, and Pruritus 

  • Other therapeutic areas available on request

NHP Biological Materials

NHP material for in vitro translational research

(limited availability, please inquire)

  • Control tissues

  • Disease tissues

  • Tissues for pharmacokinetic testing

NHP Housing

Short- and long-term housing of cynomolgus macaques

Please contact us for more details concerning our NHP models and services

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Hamamatsu Pharma Research U.S.A., Inc (Business Development Office)

400 N Tustin Ave. Ste 240 Santa Ana, CA 92705

E-mail: info_us[at]

HPR Dry AMD model