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NHP Irritable Bowel Syndrome Model Publication


Announcing publication of "Regional brain activation during rectal distention and attenuation with alosetron in a nonhuman primate model of irritable bowel syndrome," in FASEB BioAdvances.


Measurement of visceral hypersensitivity associated with IBS using brain activation. Previously DSS-treated macaques exhibited no signs of inflammation on colonoscopy or change in rectal functioning. Potential new model for development of therapeutics for an indication with few treatment options.




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